Reduction of Fructosamine Levels after Ramadan Fasting in Children with Type 1 Diabetes Mellitus

Indonesian Journal of Medicine

article

Muhammad Faizi¹  Nur Rochmah¹  Imella Marcos²  Anang Endaryanto³  Soetjipto Soetjipto⁴ 

[1] 1. Post Graduate Program, Faculty of Medicine, Airlangga University 2. Department of Child Health, Dr. Soetomo General Hospital/ Faculty of Medicine, Airlangga University;Department of Child Health, Dr. Soetomo General Hospital/ Faculty of Medicine, Airlangga University;Post Graduate Program, Faculty of Medicine, Airlangga University;Department of Biochemistry, Faculty of Medicine, Airlangga University

关键词: type 1 diabetes;    children;    fasting;    Ramadan;    fructosamine;   

DOI  :  10.26911/theijmed.2022.07.02.02

学科分类：眼科学

来源: Masters Program in Public Health, Universitas Sebelas Maret

【 摘 要 】

Background: Ramadan fasting is one religious challenge for children with type 1 diabetes mellitus (T1DM) which required specific management and strict monitoring. Fructosamine, which reflects glycemic control within 2-3 weeks, is an ideal parameter of glycemic control in Ramadan fasting. This study aimed to analyzed the effect of Ramadan fasting on fructosamine level of children with T1DM.Subjects and Method: This prospective cohort study included children aged under 18 years old diagnosed wit T1DM for >6 months at Dr. Soetomo Hospital, Surabaya, Indonesia in Ramadan 1438 H (May-June 2017). The independent variable from this study was Ramadhan fasting and the depen­dent variables were fructosamine and HbA1c. The sampling technique was total sampling. Forty-two children were included and devided into 27 children in the fasting and 15 children in the non-fasting group. Fructosamine and HbA1c levels were measured before, mid- and after Ramadan and the comparison between groups were analyzed using the independent T-test.Results: The mean age of all the subjects was 8.95 (SD=3.2) years old, 47.6% were males. The mean (SD) HbA1c level of all the subjects was 10.42 (1.16) %. There was a mild reduction of mean fructosamine level after Ramadan in the fasting group. There was no significat differece I fructsamie level before (Mean= 556.8; SD= 180.39; p= 0.620), mid (Mean= 568.07; SD= 175.37; p= 0.520), and after Ramadhan between groups (Mean= 539.41; SD= 173.04; p= 0.410) respectively. The average fructosamine levels after Ramadan was positively and strongly related to HbA1c (r=0.69; p<0.001). There was no case of severe hypoglycemia and diabetic ketoacidosis in both groups.Conclusion: There is a reduction of mean fructosamine level after Ramadan fasting in children with T1DM although it isn’t statistically significant.

【 授权许可】

CC BY-NC-SA