Cuscuta chinensis Antidepressant-Like Effect, the Role of 5-HT and the Impact on Behavioral Response in Mice

Research Journal of Pharmacognosy

article

Maryam Hamzeloo-Moghadam¹  Leila Ara²  Fatemeh Jafari²  Roshanak Mokaberinejad³ 

[1] Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences;Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences;Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences

关键词: Cuscuta chinensis;    depression;    Persian medicine;    phenolics content;   

DOI  :  10.22127/rjp.2022.338343.1885

学科分类：环境科学（综合）

来源: Iranian Society of Pharmacognosy

【 摘 要 】

Background and objectives: Depression is a chronic mental disorder that influences people’s livesand functionality. The available medications do not give full guaranty of effectiveness and are notdevoid of unwanted side effects. Cuscuta chinensis has been recommended for the treatment ofdepression in traditional medicine. In this study, the antidepressant-like activity of C. chinensis hasbeen evaluated by using forced swimming test (FST) in mice. Methods: Cuscuta chinensis extractwas provided by boiling in water. The antidepressant effect was evaluated by forced swimming test(FST) in mice with daily gavage of 270, 360 and 430 mg/kg of the treatments for four weeks. Theimmobility time and behavioral activity and also the blood levels of 5-HT and norepinephrine weremeasured. Results: The FST confirmed antidepressant effect of the extract with decreased time ofimmobility and increased swimming time alongside increase in serum 5-HT in all groups(p<0.01compared to the control) except for the extract at the dose of 270 mg/kg (MA270). This effectwas not statistically significant with fluoxetine group. Conclusion: Cuscuta chinensis demonstratedantidepressant effects in mice model which is a confirmation for its traditional use in depression.

【 授权许可】

CC BY-NC