Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior

Basic and Clinical Neuroscience

article

Fatemeh Sadat Mirfazeli¹  Fatemeh Mohebi²  Amin Jahanbakhshi³  Omid Aryani⁴  Mostafa Almasi-Dooghaee⁵ 

[1] Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences;Department of Psychiatry, School of Medicine, Iran University of Medical Sciences;Skull Base Research Center, Department of Neurosurgery, Rasool Akram Hospital, Iran University of Medical Sciences;Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences;Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences

关键词: Wolfram syndrome;    Suicidal behavior;    Gene;    Mutation;    WFS1 gene;   

DOI  :  10.32598/bcn.2021.910.3

来源: Iran University of Medical Sciences

【 摘 要 】

Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS.

【 授权许可】

Unknown