Modulatory Effects of Memantine on Neuronal Response Properties in Rat Barrel Cortex

Basic and Clinical Neuroscience

article

Mahin Nasiri¹  Ayat Kaeidi¹  Iman Fatemi²  Mahdieh Azin¹  Mahboobeh Bannazadeh¹  Mohammad Allahtavakoli¹  Ali Roohbakhsh³  Ali Shamsizadeh¹ 

[1] Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences;Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences;Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences

关键词: Memantine;    Somatosensory cortex;    Electrophysiology;    Rat;   

DOI  :  10.32598/bcn.2021.1156.2

来源: Iran University of Medical Sciences

【 摘 要 】

Introduction: Memantine as N-Methyl-D-Aspartic Acid (NMDA) receptor antagonist is used in some neurological disorders. Moreover, memantine presents modulatory effects on the somatosensory information processing in healthy subjects. This study investigated the effects of memantine on electrophysiological properties of barrel cortex neurons in male rats.  Methods: Single unit recording was used to evaluate the electrophysiological properties of barrel cortex neurons. The neural responses to the Principal Whisker (PW), Adjacent Whisker (AW), and combined displacement of two whiskers [20 ms Inter-Stimulus Intervals (ISIs)] were recorded before and 2 hours after memantine gavage (10 mg/kg). A Condition Test Ratio (CTR) was calculated for assessing inhibitory interactions.  Results: Two hours after memantine gavage, neuronal ON and OFF responses to PW deflection were decreased. Furthermore, CTR for both ON and OFF responses was decreased following memantine administration.  Conclusion: The current study demonstrated that memantine modified neural response properties in the rat barrel cortex.

【 授权许可】

Unknown