New Biomarkers Based on Smoking-Related Phenotypes for Smoking Cessation Outcomes of Nicotine Replacement Therapy: A Prospective Study

Basic and Clinical Neuroscience

article

Arash Nikkholgh¹  Soltan Ahmad Ebrahimi²  Enayatollah Bakhshi³  Mohammad-Reza Zarrindast⁴  Yazdan Asgari⁵  Anahita Torkaman-Boutorabi¹ 

[1] Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences;Department of Pharmacology, School of Medicine, Iran University of Medical Sciences;Department of Biostatistics and Epidemiology, University of Social Welfare and Rehabilitation Sciences;Iranian National Center for Addiction Studies, Tehran University of Medical Sciences;Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences

关键词: Cotinine;    Carbon monoxide;    Nicotine replacement therapy;    Smoking cessation;   

DOI  :  10.32598/bcn.2021.1552.1

来源: Iran University of Medical Sciences

【 摘 要 】

Introduction: Identifying a potent biomarker for smoking cessation can play a key role in predicting prognosis and improving treatment outcomes. This study aimed to evaluate the contribution of new biomarkers based on the levels of Cotinine (Cot) and carbon monoxide (CO) to the short- and long-term quit rates of nicotine replacement therapies (Nicotine Patch [NP] and Nicotine Lozenge [NL]). Methods: In this prospective interventional study, 124 smokers under treatment with the 5A’s method were selected from an outpatient smoking cessation center in district 18 of Tehran City, Iran. The study was conducted from April 2016 to December 2018. They were divided into NP (n=56) and NL (n=61) intervention groups. The levels of Cot and CO were measured using ELISA and breath analysis at the beginning of the study. Three markers were calculated: Cot/CO, Cot to cigarette per day ratio (Cot/CPD), and CO/CPD. Binary logistic regression models and generalized estimating equations models were analyzed by SPSS software, version 21 to determine the chances of quitting smoking. Results0.05).  Conclusion: The findings of this study suggested two markers of Cot/CO and CO/CPD in this order for the optimum treatment outcomes of NP and NL.

【 授权许可】

Unknown