Fabrication and Evaluation of Matrix Type Novel Transdermal Patch Loaded with Tramadol Hydrochloride

Turkish Journal of Pharmaceutical Sciences

article

Shankhadip NANDI¹  Saptarshi MONDAL² 

[1] Eminent College of Pharmaceutical Technology, Department of Pharmaceutics;Bengal School of Technology, Department of Pharmaceutics

关键词: Optimized transdermal patch;    tramadol hydrochloride;    ex vivo permeation studies;    higuchi diffusion kinetics;    matrix type drug delivery;   

DOI  :  10.4274/tjps.galenos.2021.43678

来源: Galenos Yayinevi

【 摘 要 】

Objectives: Transdermal drug delivery as a novel drug delivery system has become a major research interest to the scientists for its controlled drug release and improved patient compliance. This study was conducted to develop an optimized transdermal patch of tramadol hydrochloride using an appropriate amount of suitable polymers. It was also planned to control the drug permeation rate from the device to achieve a sustained release pattern. Materials and Methods: Several numbers of formulations were prepared by altering the amount of excipients. Physicochemical and biopharmaceutical parameters were checked to get the optimized formulation with desired characteristics. Results: 200) indicated the flexibility of the prepared patches and their integrity to the skin. The transdermal patches coded as F26 containing only HPMC polymer demonstrated the desired drug permeation rate (65.51%) within 12 hours through ex vivo permeation studies. Conclusion: The formulation coded as F26 was found to be the most optimized patch as it exhibited sustained drug permeation rate followed by higuchi diffusion kinetics, that also confirmed the capability of the formulation to exhibit matrix type drug delivery.

【 授权许可】

Unknown