Preparation and Characterization of Orlistat Bionanocomposites Using Natural Carriers

Turkish Journal of Pharmaceutical Sciences

article

Santosh PAYGHAN¹  Vaishali PAYGHAN¹  Kavita NANGARE¹  Lalita DAHIWADE¹  Karna KHAVANE²  Ram PHALKE³ 

[1] Vasantidevi Patil Institute of Pharmacy, Kodoli, Department of Pharmaceutics;Gurunanak Institute of Pharmacy, Department of Pharmaceutics;Tatyasaheb Kore College of Pharmacy, Department of Pharmaceutics

关键词: Bionanocomposite;    BCS class II;    orlistat;    Moringa oliefera;    Aegle marmelos;    microwave-assisted fusion method;    Hansen parameters parameter;   

DOI  :  10.4274/tjps.galenos.2021.71363

来源: Galenos Yayinevi

【 摘 要 】

Objectives: Bionanocomposites (BNCs) are biopolymers or a natural polymers embedded in a combination of two or more different chemicals using natural carriers or bio. BNCs are widely used in drug formulation and in the development of new drugs for various therapeutic drugs, new dosage forms and in pharmacological medicine. Materials and Methods: Useful and improved melting was achieved by converting selected Biopharmaceutics Classification System (BCS) class II drug into BNCs using natural carriers such as the gums of Moringa oleifera Lam. and Aegle marmelos (L.) Correa, respectively. The current work focuses on the enhancement of the novel natural polymers such as M. oleifera and A. marmelos, used to prepare BNC for BCS class II orlistat using a microwave system designed for the distribution method. The natural polymer helps improve the melting of the dispersion when it converts them into BNC. Definitions of orlistat, natural carriers, and prepared BNCs were developed and studied comparatively. The fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) study revealed that there was no communication between drug associations and environmental carriers. Results: Crowd reduction studies were conducted to investigate the material that enhances the melting of BNC compounds dissolving and in vitro disposal of BNCs prepared by DSC, scanning electron microscopy, X-ray diffraction studies, and FTIR. BNCs affect orlistat: M. oleifera (OSMO-BNC- 1: 3), orlistat: A. marmelos (OSAM-BNC- 1: 4) is well developed. Conclusion: Ornat BNCs developed with M. oleifera and A. marmelos provide significant improvements in dissolve and highlight their use in reducing fortification. Additionally, land melting limits were applied and determined for the melting of BNCs prepared using the Hansen Solubility parameters in particular, Hoy’s, Fedor and Van Krevelen system and it was found that this report there was a significant increase in the melting of batches prepared for BNCs.

【 授权许可】

Unknown