The Ameliorate Effects of Nerolidol on Thioacetamide-induced Oxidative Damage in Heart and Kidney Tissue

Turkish Journal of Pharmaceutical Sciences

article

Neşe Başak TÜRKMEN¹  Hande YÜCE¹  Aslı TAŞLIDERE²  Yasemin ŞAHİN³  Osman ÇİFTÇݳ 

[1] İnönü University Faculty of Pharmacy, Department of Pharmaceutical Toxicology;İnönü University Faculty of Medicine, Department of Histology and Embryology;Pamukkale University Faculty of Medicine, Department of Medicinal Pharmacology

关键词: Nerolidol;    thioacetamide;    lipid peroxidation;    nephrotoxicity;    cardiotoxicity;   

DOI  :  10.4274/tjps.galenos.2021.30806

来源: Galenos Yayinevi

【 摘 要 】

Objectives: Thioacetamide (TAA) is an organosulfur, white crystalline compound having liver injury. However, it shows toxic effects on many organs. The reverts the oxidative stress created by TAA on the heart and kidney, and decreased lipid peroxide peroxidation back with antioxidant-properties nerolidol (NRL). This study hypothesized that NRL treatment a potential ameliorate nephrotoxicity and cardiotoxicity caused by TAA. Materials and Methods: Thirty-two Wistar Albino male rats (3-4 months old and 280-300 g in weight) were divided into four groups. (a) Control, (b) TAA was administered 200 mg/kg i.p. twice a weekly (c) NRL was orally administered at the dose of 100 mg/kg per every other day by gavages. (d) TAA and NRL-treated groups were assigned 200 mg/kg TAA and 100 mg/kg NRL for three weeks. Results: As a result of these dose administration thiobarbituric acid reactive substances (TBARS) levels, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx) levels were detected. The results were shown that TAA leads to a significant rise in TBARS level and a significant decrease in GPx, CAT, SOD, and GSH levels in the heart and kidney tissue according to the control group. The finding of this study the NRL treatment reduced TBARS levels and increased antioxidant level. Administration of NRL prevents the biochemical and histopathological alterations induced by TAA. Conclusion: The findings of this study show that the antioxidant activity of NRL can protect against biochemical and histological damage caused by TAA in heart and kidney tissue.

【 授权许可】

Unknown