Isoflavones in Soybean as a Daily Nutrient: The Mechanisms of Action and How They Alter the Pharmacokinetics of Drugs

Turkish Journal of Pharmaceutical Sciences

article

Amelia SOYATA¹  Aliya Nur HASANAH²  Taofik RUSDIANA¹ 

[1] Padjadjaran University Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology;Padjadjaran University Faculty of Pharmacy, Department of Analysis of Pharmaceutical and Medical Chemistry

关键词: Soybean;    isoflavones;    pharmacokinetic ınteraction;    drug metabolizing enzyme;    drug transporter;   

DOI  :  10.4274/tjps.galenos.2020.79106

来源: Galenos Yayinevi

【 摘 要 】

Soybeans [Glycine max (L.)] are a good source of isoflavones. The main isoflavone components of soybean are daidzein, genistein, and glycitein. World soybean production is very high. Because of its pharmacological activity, soy isoflavone intake over a long period of time may result in interactions with the drugs. This review summarizes soy isoflavone-drug interactions based on the pharmacokinetic parameters. Soy isoflavones have pharmacokinetic interactions with celecoxib, theophylline, paclitaxel, midazolam, imatinib, carbamazepine, valproic acid, repaglinide, omeprazole and danofloxacin. This is due to the changes in the area under the curve, maximum serum concentration, time that a drug is present at the maximum concentration in serum, clearance and half-life of the drugs when delivered together with soy isoflavones. The mechanisms of pharmacokinetic interactions occurs through the inhibition/induction of drug metabolizing cytochrome P450 (CYP450) enzymes such as CYP3A4, CYP2A1, and CYP2C9 or through the inhibition of drug transporters such as P-glycoprotein and breast cancer resistance protein. Thus, the consumption of soybean, soy isoflavones or soy products with drugs needs to be reconsidered.

【 授权许可】

Unknown