Investigation of the influential factors for hepatic osteodystrophy in chronic liver disease: A case–control survey among the patients attending a tertiary care hospital in a rural region of Northern India

Tzu Chi Medical Journal

article

Ekta Yadav¹  Rupan Deep Kaur²  Aayushi Sasan³  Sunny Garg⁴ 

[1] Department of Medicine, Bhagat Phool Singh Government Medical College for Women Sonipat;Department of Transfusion Medicine, Bhagat Phool Singh Government Medical College for Women;Bhagat Phool Singh Government Medical College for Women;Department of Psychiatry, Bhagat Phool Singh Government Medical College for Women

关键词: Bone mineral density;    Chronic liver disease;    Hepatic osteodystrophy;    Risk factorsmagnitude;   

DOI  :  10.4103/tcmj.tcmj_27_22

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Objectives: Hepatic osteodystrophy (HOD) is a well‑recognized complication of chronic liver diseases (CLD), but the influential factors associated with this complication were studied scarcely in a rural Indian population. The study aims to evaluate the prevalence of HOD and variables that might influence it among cases diagnosed with CLD. Materials and Methods:18 years) and gender matched in a period between April and October 2021. They were subjected to etiological workup, hematological and biochemical investigations, and Vitamin D levels. Then, dual‑energy X‑ray absorptiometry was used to measure the bone mineral densitometry (BMD) for whole‑body, lumbar spine (LS), and hip. HOD was diagnosed according to the WHO criteria. Then, the Chi‑square test and conditional logistic regression analysis were used to investigate the influential factors of HOD in CLD patients. Results:60 years), and in both the male and female patients. HOD was found in 70% of CLD patients. After multivariate analysis in CLD patients, we identified that being a male patient (odds ratio [OR] = 3.03), older age (OR = 3.54), duration of illness for more than 5 years (OR = 3.89), decompensated liver dysfunction with Child–Turcotte–Pugh‑B and C grading (OR = 8.28), and low level of Vitamin D (OR = 18.45) were the risk factors for HOD. Conclusion: This study concludes that severity of illness and lower level of Vitamin D were the main influential factors for HOD. Supplementation of Vitamin D and calcium in the patients can abate the risk of fractures in our rural communities.

【 授权许可】

Unknown