期刊论文详细信息
Plastic and Reconstructive Surgery, Global Open | |
Reconstitution of Injectable Poly- d , l -lactic Acid: Efficacy of Different Diluents and a New Accelerating Method | |
article | |
Se-Yi Chen1  Szu-Ting Chen3  Jui-Yu Lin4  Chuan-Yuan Lin1  | |
[1]Department of Neurosurgery, Chung-Shan Medical University Hospital | |
[2]School of Medicine, Chung-Shan Medical University | |
[3]Institute of Clinical Medicine, National Yang-Ming University | |
[4]Tobeauty Aesthetic Clinic | |
DOI : 10.1097/GOX.0000000000002829 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Wolters Kluwer | |
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【 摘 要 】
Background: Injectable poly-d,l-lactic acid (PDLLA) is a new collagen-stimulating filler containing PDLLA microspheres and carboxymethyl cellulose. It is available as a lyophilized powder that must be reconstituted with a diluent before administration. The aims of this study were to investigate the efficacy of different diluents and a new accelerating “back-and-forth” method. Methods: Six different diluents, sodium bicarbonate, sterile water for injection (SWFI), normal saline, lidocaine, lidocaine with epinephrine (lidocaine + E), and mannitol, were tested. The recommended “vortex” method for preparation of thin suspensions and a new back-and-forth method suitable for both thin and thick suspensions were compared. Gross and microscopic views of the prepared suspensions were examined. Results: Using the vortex method, only mannitol and SWFI are found to be effective reconstitution diluents for injectable PDLLA. Using the back-and-forth method, all six diluents can be used for reconstitution of injectable PDLLA. Moreover, the time needed for reconstitution of injectable PDLLA by this back-and-forth method is very short, regardless of the thickness of the suspension. Conclusions: Clinically, only SWFI can be used for reconstitution of injectable PDLLA by “hand-shaking” or vortex method. To accelerate the reconstitution time especially when using small amount of SWFI, back-and-forth is the method of choice. Besides, when SWFI is not available, other diluents such as normal saline, lidocaine, or lidocaine + E can be used by this novel back-and-forth reconstitution method.【 授权许可】
CC BY-NC-ND
【 预 览 】
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