ALGINATE versus NPWT in the Preparation of Surgical Excisions for an STSG: ATEC Trial

Plastic and Reconstructive Surgery, Global Open

article

Dominique Casanova¹  Pierre Guerreschi²  Raphael Sinna³  Nicolas Bertheuil⁴  Cécile Philandrianos¹  Bérengère Chignon-Sicard⁵  Franck Duteille⁶  Michael Atlan⁷  Pascal Rousseau⁸  Gilles Chatellier⁹  Fabien Boucher^1,10  Nathalie Pham Dang^1,11  Adeline Cambon-Binder^1,12  Audrey Michot^1,13  Isabelle Pluvy^1,14  Frédéric Seigle-Murandi^1,15  Weiguo Hu^1,16  Marc Revol¹ 

[1]Department of Plastic and Reconstructive Surgery, Hospital Conception

[2]Department of Plastic, Cosmetic and Reconstructive Surgery, Regional and University Hospital Centre Lille

[3]Department of Plastic, Cosmetic and Reconstructive Surgery, University Hospital Centre Amiens-Picardie

[4]Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital Centre Rennes

[5]Department of Plastic, Cosmetic and Reconstructive Surgery, University Hospital Centre Nice

[6]Department of Plastic, Cosmetic and Reconstructive Surgery, University Hospital Centre Nantes

[7]Department of Plastic, Cosmetic and Reconstructive Surgery, Hospital Tenon

[8]Department of Plastic, Cosmetic and Reconstructive Surgery, University Hospital Centre Angers

[9]Unité de Recherche Clinique, European Hospital Group Georges-Pompidou

[10]Department of Burns, Plastic, Cosmetic and Reconstructive Surgery, University Hospital Centre Lyon

[11]Department of Maxillofacial and Plastic Surgery, University Hospital Centre Clermont-Ferrand

[12]Department of Orthopaedic and Hand Surgery, Hospital Saint-Antoine

[13]Department of Plastic and Reconstructive Surgery, University Hospital Centre Bordeaux

[14]Department of Plastic Surgery, University Hospital Centre Besancon

[15]Department of Plastic, Cosmetic and Reconstructive Surgery, University Hospital Centre Strasbourg

[16]Department of Plastic, Cosmetic and Reconstructive Surgery, University and Regional Hospital Centre Brest

DOI  :  10.1097/GOX.0000000000002691

学科分类：社会科学、人文和艺术（综合）

来源: Wolters Kluwer

【 摘 要 】

Background:  A calcium alginate dressing (ALGINATE) and negative pressure wound therapy (NPWT) are frequently used to treat wounds which heal by secondary intention. This trial compared the healing efficacy and safety of these 2 treatments. Methods:  30 cm2), which was left open to heal by secondary intention. They received ALGINATE or NPWT by a centralized randomization. Follow-up was performed weekly until optimal granulation tissue was obtained. The primary outcome was time to obtain optimal granulation tissue for a split thickness skin graft take (non-inferiority margin: 4 days). Secondary outcomes were occurrence of adverse events (AEs) and impact of the treatments on the patient’s daily life. Results:  ALGINATE and NPWT were applied to 47 and 48 patients, respectively. The mean time to optimal granulation was 19.98 days (95% CI, 17.7–22.3) with ALGINATE and 20.54 (95% CI, 17.6–23.5) with NPWT. Between group difference was −0.56 days (95% CI −4.22 to 3.10). The non-inferiority of ALGINATE versus NPWT was demonstrated. No AE related to the treatment occurred with ALGINATE versus 14 AEs with NPWT. There was no difference in the impact of the treatments on the patient’s daily life. Conclusion:  This trial demonstrates that ALGINATE has a similar healing efficacy to that of NPWT and that is markedly better with regard to patient safety.

【 授权许可】

CC BY-NC-ND