Visualizing surface marker expression and intratumoral heterogeneity with SERRS-NPs imaging

Nanotheranostics

article

Lara K. Rotter¹  Naxhije Berisha²  Hsiao-Ting Hsu²  Kathleen H. Burns⁸  Chrysafis Andreou²  Moritz F. Kircher² 

[1] Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Harvard University Medical School;Department of Radiology, Memorial Sloan Kettering Cancer Center;Department of Neurology, Memorial Sloan Kettering Cancer Center;Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University Munich;PhD Program in Chemistry, The Graduate Center of the City University of New York;Department of Nanotechnology, Advanced Science Research Center ,(ASRC) at the Graduate Center of the City University of New York;Department of Pharmacology, Memorial Sloan Kettering Cancer Center;Department of Pathology, Dana-Farber Cancer Institute and Harvard University Medical School;Department of Electrical and Computer Engineering University of Cyprus;Molecular Pharmacology Program, Memorial Sloan Kettering Institute;Department of Radiology, Weill Cornell Medical College;Department of Imaging, Dana-Farber Cancer Institute

关键词: SERRS;    Raman imaging;    Raman Nanoparticles;    Raman Spectroscopy;    Brain tumor;    Glioblastoma multiforme;    Breast Cancer;    Breast Cancer Metastasis;    Tumor Heterogeneity;    Surface marker expression;    EGFR;    HER2.;   

DOI  :  10.7150/ntno.67362

学科分类：大气科学

来源: Ivyspring International Publisher

【 摘 要 】

Cell surface marker expression in tumors dictates the selection of therapeutics, therapy response, and survival. However, biopsies are invasive, sample only a small area of the tumor landscape and may miss significant areas of heterogeneous expression. Here, we investigated the potential of antibody-conjugated surface-enhanced resonance Raman scattering nanoparticles (SERRS-NPs) to depict and quantify high and low tumoral surface marker expression, focusing on the surface markers epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) in an intracerebral and peripheral setting with an inter- and intratumoral comparison of Raman signal intensities.

【 授权许可】

CC BY-NC