Lipid nitroalkene nanoparticles for the focal treatment of ischemia reperfusion

Nanotheranostics

article

Gary Z Yu¹  Thiruganesh Ramasamy¹  Marco Fazzari²  Xucai Chen¹  Bruce Freeman²  John J Pacella¹ 

[1] Center for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine, University of Pittsburgh;Department of Pharmacology and Chemical Biology, University of Pittsburgh

关键词: ultrasound-targeted lipid nanoparticle cavitation;    microvascular obstruction;    acute myocardial infarction;    inflammation;    nitro-fatty acid;    nitroalkene;   

DOI  :  10.7150/ntno.62351

学科分类：大气科学

来源: Ivyspring International Publisher

【 摘 要 】

Rationale: The treatment of microvascular obstruction (MVO) using ultrasound-targeted LNP cavitation (UTC) therapy mechanically relieves the physical obstruction in the microcirculation but does not specifically target the associated inflammatory milieu. Electrophilic fatty acid nitroalkene derivatives (nitro-fatty acids), that display pleiotropic anti-inflammatory signaling and transcriptional regulatory actions, offer strong therapeutic potential but lack a means of rapid targeted delivery. The objective of this study was to develop nitro-fatty acid-containing lipid nanoparticles (LNP) that retain the mechanical efficacy of standard LNP and can rapidly target delivery of a tissue-protective payload that reduces inflammation and improves vascular function following ischemia-reperfusion.

【 授权许可】

CC BY-NC