期刊论文详细信息
Nanotheranostics | |
Prostate-specific membrane antigen (PSMA)-targeted photodynamic therapy enhances the delivery of PSMA-targeted magnetic nanoparticles to PSMA-expressing prostate tumors | |
article | |
Sangeeta R. Banerjee1  Ethel J. Ngen1  Ying Chen1  Babak Behnam Azad1  Srikanth Boinapally1  Desmond Jacob1  Ala Lisok1  Chentian Shen1  Mir S. Hossain1  Jiefu Jin1  Zaver M. Bhujwalla1  Martin G. Pomper1  | |
[1] The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine;The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine | |
关键词: prostate cancer; magnetic nanoparticle delivery; photodynamic therapy (PDT); enhanced permeability and retention (EPR) effect; magnetic resonance imaging (MRI); | |
DOI : 10.7150/ntno.52361 | |
学科分类:大气科学 | |
来源: Ivyspring International Publisher | |
【 摘 要 】
Enhanced vascular permeability in tumors plays an essential role in nanoparticle delivery. Prostate-specific membrane antigen (PSMA) is overexpressed on the epithelium of aggressive prostate cancers (PCs). Here, we evaluated the feasibility of increasing the delivery of PSMA-targeted magnetic nanoparticles (MNPs) to tumors by enhancing vascular permeability in PSMA(+) PC tumors with PSMA-targeted photodynamic therapy (PDT).
【 授权许可】
CC BY-NC
【 预 览 】
Files | Size | Format | View |
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RO202307110002480ZK.pdf | 2436KB | download |