Prostate-specific membrane antigen (PSMA)-targeted photodynamic therapy enhances the delivery of PSMA-targeted magnetic nanoparticles to PSMA-expressing prostate tumors

Nanotheranostics

article

Sangeeta R. Banerjee¹  Ethel J. Ngen¹  Ying Chen¹  Babak Behnam Azad¹  Srikanth Boinapally¹  Desmond Jacob¹  Ala Lisok¹  Chentian Shen¹  Mir S. Hossain¹  Jiefu Jin¹  Zaver M. Bhujwalla¹  Martin G. Pomper¹ 

[1] The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine;The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine

关键词: prostate cancer;    magnetic nanoparticle delivery;    photodynamic therapy (PDT);    enhanced permeability and retention (EPR) effect;    magnetic resonance imaging (MRI);   

DOI  :  10.7150/ntno.52361

学科分类：大气科学

来源: Ivyspring International Publisher

【 摘 要 】

Enhanced vascular permeability in tumors plays an essential role in nanoparticle delivery. Prostate-specific membrane antigen (PSMA) is overexpressed on the epithelium of aggressive prostate cancers (PCs). Here, we evaluated the feasibility of increasing the delivery of PSMA-targeted magnetic nanoparticles (MNPs) to tumors by enhancing vascular permeability in PSMA(+) PC tumors with PSMA-targeted photodynamic therapy (PDT).

【 授权许可】

CC BY-NC