MR-labelled liposomes and focused ultrasound for spatiotemporally controlled drug release in triple negative breast cancers in mice

Nanotheranostics

article

Maral Amrahli¹  Miguel Centelles¹  Paul Cressey¹  Martynas Prusevicius¹  Wladyslaw Gedroyc²  Xiao Yun Xu³  Po-Wah So⁴  Michael Wright¹  Maya Thanou¹ 

[1] School of Cancer & Pharmaceutical Sciences, King's College London;Department of Academic Surgery, Imperial College London;Department of Chemical Engineering, Imperial College London;Department of Neuroimaging, King's College London

关键词: liposome;    MRI;    focused ultrasound;    doxorubicin;    triple-negative breast cancer;   

DOI  :  10.7150/ntno.52168

学科分类：大气科学

来源: Ivyspring International Publisher

【 摘 要 】

Rationale: Image-guided, triggerable, drug delivery systems allow for precisely placed and highly localised anti-cancer treatment. They contain labels for spatial mapping and tissue uptake tracking, providing key location and timing information for the application of an external stimulus to trigger drug release. High Intensity Focused Ultrasound (HIFU or FUS) is a non-invasive approach for treating small tissue volumes and is particularly effective at inducing drug release from thermosensitive nanocarriers. Here, we present a novel MR-imageable thermosensitive liposome (iTSL) for drug delivery to triple-negative breast cancers (TNBC).

【 授权许可】

CC BY-NC