Multifunctional microfluidic chip for cancer diagnosis and treatment

Nanotheranostics

article

Qiao-ru Guo¹  Ling-ling Zhang¹  Ji-fang Liu¹  Zhen Li²  Jia-jun Li¹  Wen-min Zhou¹  Hui Wang³  Jing-quan Li⁴  Da-yu Liu⁵  Xi-yong Yu¹  Jian-ye Zhang¹ 

[1] Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University;Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University;Guangzhou Institute of Pediatrics/Guangzhou Women and Children's Medical Center, Guangzhou Medical University;The First Affiliated Hospital, Hainan Medical University;Department of Laboratory Medicine, Guangzhou First People's Hospital, School of Medicine, South China University of Technology

关键词: Microfluidic chip;    Cancer;    Preclinical model;    Drug screening;    Biomarker;    Nanoparticle;   

DOI  :  10.7150/ntno.49614

学科分类：大气科学

来源: Ivyspring International Publisher

【 摘 要 】

Microfluidic chip is not a chip in the traditional sense. It is technologies that control fluids at the micro level. As a burgeoning biochip, microfluidic chips integrate multiple disciplines, including physiology, pathology, cell biology, biophysics, engineering mechanics, mechanical design, materials science, and so on. The application of microfluidic chip has shown tremendous promise in the field of cancer therapy in the past three decades. Various types of cell and tissue cultures, including 2D cell culture, 3D cell culture and tissue organoid culture could be performed on microfluidic chips. Patient-derived cancer cells and tissues can be cultured on microfluidic chips in a visible, controllable, and high-throughput manner, which greatly advances the process of personalized medicine. Moreover, the functionality of microfluidic chip is greatly expanding due to the customizable nature. In this review, we introduce its application in developing cancer preclinical models, detecting cancer biomarkers, screening anti-cancer drugs, exploring tumor heterogeneity and producing nano-drugs. We highlight the functions and recent development of microfluidic chip to provide references for advancing cancer diagnosis and treatment.

【 授权许可】

CC BY-NC