Supramolecular Polysaccharide Nanotheranostics that Inhibit Cancer Cells Growth and Monitor Targeted Therapy Response

Nanotheranostics

article

Nilesh Deshpande¹  Anujan Ramesh²  Dipika Nandi³  Anh Nguyen¹  Anthony Brouillard¹  Ashish Kulkarni¹ 

[1] Department of Chemical Engineering, University of Massachusetts;Depatment of Biomedical Engineering, University of Massachusetts;Department of Veterinary and Animal Science, University of Massachusetts;Center for Bioactive Delivery, Institute for Applied Life Sciences, University of Massachusetts

关键词: Polysaccharide;    Nanotheranostics;    Supramolecular Chemistry;    Kinase inhibitor Delivery;    Cancer;   

DOI  :  10.7150/ntno.44703

学科分类：大气科学

来源: Ivyspring International Publisher

【 摘 要 】

Targeted anticancer therapies directed against specific molecular drivers of tumors are emerging as effective treatment strategies, however, monitoring their response is still challenging. Current clinical imaging techniques that measure either morphological or metabolic changes in the tumor are not always indicative of clinical outcome due to delayed or variable responses. Here, dual-stage polysaccharide-based supramolecular nanotheranostics (SPN) were designed that enable co-delivery of kinase inhibitor and an activatable imaging probe.

【 授权许可】

CC BY-NC