Preclinical evaluation of cationic DOTA-triarginine-lipid conjugates for theranostic liquid brachytherapy

Nanotheranostics

article

Wenbo Wang¹  Frederikke P. Fliedner³  Anders E. Hansen¹  Rasmus Eliasen¹  Fredrik Melander¹  Andreas Kjaer³  Thomas L. Andresen¹  Andreas I. Jensen⁴  Jonas R. Henriksen¹ 

[1] Department of Health Technology, Technical University of Denmark;Center for Nanomedicine and Theranostics, Technical University of Denmark;Rigshospitalet and University of Copenhagen, Dept. of Clinical Physiology, Nuclear Medicine & PET;The Hevesy Laboratory, Department of Health Technology, Technical University of Denmark

关键词: brachytherapy;    radiotherapy;    cancer;    intratumoral;    micelles;   

DOI  :  10.7150/ntno.44562

学科分类：大气科学

来源: Ivyspring International Publisher

【 摘 要 】

Liquid brachytherapy is an emerging technology for internal radiation therapy where liquids containing radionuclides are administered directly into solid tumors. These technologies are less invasive than conventional brachytherapy, and can potentially improve the dose coverage and homogeneity of the radioactivity distribution within the tumor. For this purpose, we have developed a novel cationic micelle system for delivery of a range of radionuclides. The system is applicable for emitters of alpha, beta or photon radiation, and enables dose-mapping via theranostic nuclear imaging.

【 授权许可】

CC BY-NC