Epidemiologic Study of Patients with Chronic Vesiculobullous Lesions

Journal of Research in Dental and Maxillofacial Sciences

article

F lavaee¹  B Vahdatifar²  B Afroozi³  F Tavakoli⁴ 

[1] Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences;School of Dentistry, Shiraz University of Medical Sciences;Oral and Maxillofacial Medicine Department, School of Dentistry, Yasuj University of Medical Sciences;Oral and Dental Disease Research Center, Oral and Maxillofacial Medicine Department, School of Dentistry, Shiraz University of Medical Sciences

关键词: Pemphigoid;    Bullous;    Pemphigus;    Mucous Membrane;   

DOI  :  10.52547/jrdms.7.3.162

学科分类：社会科学、人文和艺术（综合）

来源: Islamic Azad University

【 摘 要 】

Background and Aim: Vesiculobullous diseases (VBDs) are characterized by the formation of vesicles or bullae. The aim of this study was to perform an epidemiological survey on patients with chronic VBDs referred to Shiraz Dental School during 2006-2016.    Materials and Methods: In this retrospective cross-sectional study, epidemiological data (age, sex, prevalence, involvement location, prescribed medication, and underlying diseases) of patients diagnosed with VBDs were collected. The relationship between the epidemiological factors and the occurrence of VBDs was analyzed. SPSS version 18 was used to analyze the data by the Chi-square test and Spearman’s correlation test.Results: Totally, 120 patients were evaluated; out of which, 88.3% had pemphigus vulgaris (PV), 4.2% had bullous pemphigoid (BP), 6.8% had mucous membrane pemphigoid (MMP), and 0.1% had pemphigus herpetiformis (PH). Most patients were females (68.3%) and 31.7% were males. The mean age of patients was 43.14±11.41 years. The mucosal and cutaneous involvement in PV patients was as follows: 31.13% had mucosal, 0.94% had cutaneous, 37.73% had both mucosal and cutaneous, and 30.18% had mucosal-cutaneous involvement associated with involvement of other organs. Prednisolone was the first-line treatment in all patients. There was a significant correlation between age and incidence of VBDs in patients (P=0.030).Conclusion: Our findings indicated that the epidemiological properties of VBDs in our study were similar to those in other countries. However, PV was the most common VBD followed by BP.

【 授权许可】

CC BY