Theoretical and electrochemical analysis of L-serine modified graphite paste electrode for dopamine sensing applications in real samples

Journal of Electrochemical Science and Engineering

article

Revanappa SanthoshKumar¹  Gururaj Kudur Jayaprakash²  Siddalinganahalli Manjappa¹  MohanKumar⁴  Avvaru Praveen Kumar⁵ 

[1] Department of Chemistry, University B.D.T. College of Engineering, Visvesvaraya Technological University;Laboratory of Quantum Electrochemistry, School of Advanced Chemical Sciences, Shoolini University;Department of Chemistry, Nitte Meenakshi Institute of Technology;Department of Chemistry, PES Institute of Technology and Management;Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University

关键词: Amino acid;    redox reaction;    quantum chemical modelling;    voltammetry;    sensor;    dopamine;   

DOI  :  10.5599/jese.1390

学科分类：内科医学

来源: International Association of Physical Chemists (IAPC)

【 摘 要 】

In this study, the carbon paste electrode (CPE) was modified by grinding L-serine in a pestle and mortar. L-serine (L-s) was shown to be an effective electrocatalyst at the modified CPE (MCPE) interface for detecting dopamine (DA). L-sMCPE showed excellent activity to detect DA in commercial injection samples with a recovery range of 98.9 to 100.5 %. Theoretical studies were used to understand the electrocatalysis of L-serine at the atomic level using frontier molecular orbitals (FMO) and analytical Fukui assay. According to theoretical findings, the amine group of L-serine works as an extra oxidation site (reason for enhanced reduction peak DA) and the carboxylic acid group acts as an additional reduction site (reason for enhanced oxidation peak DA) at the L-sMCPE interface.

【 授权许可】

CC BY