Anticonvulsant Drugs and Severe Adverse Cutaneous Drug Reactions: A Longitudinal Observational Study

Caspian Journal of Neurological Sciences

article

Abbas Darjani¹  Narges Alizadeh¹  Hossein Abdi¹  Maryam Hosseini¹  Shirin Zaresharifi² 

[1] Skin Research Center, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences;Skin Research Center, Shahid Beheshti University of Medical Science

关键词: Drug eruptions;    Anticonvulsants;    Skin;   

DOI  :  10.32598/CJNS.5.18.127

学科分类：社会科学、人文和艺术（综合）

来源: Presses Agronomiques De Gembloux

【 摘 要 】

Background: Severe Adverse Cutaneous Reactions to Drugs (SACRDs) are skin eruptions due to drugs, which can cause morbidity and morbidity in patients. Objectives: The aim of this study was to determine the offending drug/agents and clinical phenotypes of SACRDs leading to admissions to the hospital. Materials & Methods: We conducted a retrospective cross-sectional study during one year (March 2012-2013) on patients admitted to the department of Dermatology at Razi Hospital of Rasht, Iran. First, the clinical and drug history of all patients were collected. Then, two dermatologists examined them and diagnosed drug eruptions according to the clinical types of adverse drug reactions included in the study. Collected data were analyzed in SPSS V. 18 software by using Chi-squared test, Fisher's Exact test, and one-way ANOVA. The significance level was set at p<0.05. Results: Forty-six patients were diagnosed with SACRDs. The most common SACRDs were toxic epidermal necrolysis/stevens Johnson syndrome (TEM/SJS) and Drug Reaction with eosinophilia and systemic symptom syndrome (DRESS) syndrome (30.5% and 2.1%, respectively). The most common culprit drugs were anticonvulsants (43.5%) and antibiotics (26.1%). Peripheral blood eosinophilia was observed in 30.4% of patients. Conclusion: Anticonvulsants were the most common cause of ACDRs, leading to the hospitalization of the patients.

【 授权许可】

CC BY-NC