Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination

Gates Open Research

article

Bryan Greenhouse¹  Jennifer Daily²  Caterina Guinovart³  Bronner Goncalves⁵  James Beeson⁶  David Bell⁷  Michelle A. Chang⁸  Justin M. Cohen⁹  Xavier Ding^1,10  Gonzalo Domingo⁴  Thomas P. Eisele^1,11  Patrick J. Lammie⁸  Alfredo Mayor³  Nicolas Merienne^1,12  Wuelto Monteiro^1,13  John Painter⁸  Isabel Rodriguez¹  Michael White^1,12  Chris Drakeley⁵  Ivo Mueller^1,14 

[1] Department of Medicine,, University of California San Francisco;UNITAID;ISGlobal, Hospital Clínic - Universitat de Barcelona;PATH;London School of Tropical Medicine & Hygiene;The Burnet Institute;Intellectual Ventures;Centers of Disease Control and Prevention;Clinton Health Access Initiative;FIND;Center for Applied Malaria Research and Evaluation, Tulane School of Public Health and Tropical Medicine;Institut Pasteur;Tropical Medicine Foundation Dr. Heitor Viera Dourado;Walter and Eliza Hall Institute of Medical Research

关键词: Malaria;    Serology;    Use Cases;    Elimination;   

DOI  :  10.12688/gatesopenres.12897.1

学科分类：电子与电气工程

来源: American Journal Of Pharmtech Research

【 摘 要 】

Measurement of malaria specific antibody responses represents a practical and informative method for malaria control programs to assess recent exposure to infection. Technical advances in recombinant antigen production, serological screening platforms, and analytical methods have enabled the identification of several target antigens for laboratory based and point-of-contact tests. Questions remain as to how these serological assays can best be integrated into malaria surveillance activities to inform programmatic decision-making. This report synthesizes discussions from a convening at Institut Pasteur in Paris in June 2017 aimed at defining practical and informative use cases for serology applications and highlights five programmatic uses for serological assays including: documenting the absence of transmission; stratification of transmission; measuring the effect of interventions; informing a decentralized immediate response;  and testing and treating P. vivax hypnozoite carriers.

【 授权许可】

CC BY