Contraceptive implant failures among women using antiretroviral therapy in western Kenya: a retrospective cohort study

Gates Open Research

article

Anne Pfitzer¹  Jacqueline Wille¹  Jonesmus Wambua¹  Stacie C Stender¹  Molly Strachan¹  Christine Maricha Ayuyo²  Timothy F. Kibidi Muhavi³  Valentino Wabwile¹  Supriya D. Mehta⁴  Elizabeth Sasser¹ 

[1] Jhpiego;Independent Consultant;Center for Health Solutions;School of Public Health, University of Illinois at Chicago

关键词: Drug interactions;    contraceptive implants;    contraception;    ART;    HIV;   

DOI  :  10.12688/gatesopenres.12975.2

学科分类：电子与电气工程

来源: American Journal Of Pharmtech Research

【 摘 要 】

Background: Women living with HIV have the right to choose whether, when and how many children to have. Access to antiretroviral therapy (ART) and contraceptives, including implants, continues to increase in Kenya. Studies have reported drug-drug interactions leading to contraceptive failures among implant users on ART. This retrospective record review aimed to determine unintentional pregnancy rates among women 15-49 years of age, living with HIV and concurrently using implants and ART in western Kenya between 2011 and 2015. Methods: We reviewed charts of women with more than three months of concurrent implant and ART use. Implant failure was defined as implant removal due to pregnancy or birth after implant placement, but prior to scheduled removal date. The incidence of contraceptive failure was calculated by woman-years at risk, assuming a constant rate. Results0.01). Conclusions: Our findings highlight the implications of drug-drug interaction on women’s choices for contraception.

【 授权许可】

CC BY