Quantifying long-term health and economic outcomes for survivors of group B Streptococcus invasive disease in infancy: protocol of a multi-country study in Argentina, India, Kenya, Mozambique and South Africa

Gates Open Research

article

Philipp Lambach¹  Mark Jit²  Joy E. Lawn⁵  Proma Paul⁵  Simon R. Procter⁵  Ziyaad Dangor⁶  Quique Bassat⁷  Amina Abubakar^1,12  Sridhar Santhanam^1,14  Romina Libster^1,15  Bronner P. Gonçalves⁵  Shabir A. Madhi⁶  Azucena Bardají⁷  Eva Mwangome^1,12  Adam Mabrouk^1,12  Hima B. John^1,14  Clara Sánchez Yanotti^1,15  Jaya Chandna⁵  Pamela Sithole⁶  Humberto Mucasse⁸  Patrick V. Katana^1,12  Artemis Koukounari⁵  Lois M. Harden^1,18  Celine Aerts⁷  Azra Ghoor^1,19  Shannon Leahy^1,19  Sibongile Mbatha^1,19  Sarah Lowick^1,19  Sanjay G. Lala^1,19  Justina Bramugy⁸  Charles Newton^1,12  A. K. M. Tanvir Hossain^2,21  Qazi Sadeq-ur Rahman^2,21 

[1] Department of Immunization, Vaccines and Biologicals ,(IVB), World Health Organization;Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine;Modelling and Economics Unit, Public Health England;Division of Epidemiology and Biostatistics, School of Public Health, University of Hong Kong;Maternal, Adolescent, Reproductive & Child Health ,(MARCH) Centre, London School of Hygiene & Tropical Medicine;Medical Research Council: Vaccines and Infectious Diseases Analytical Unit, Faculty of Health Sciences, University of the Witwatersrand;ISGlobal, Hospital Clínic, Universitat de Barcelona;Centro de Investigação em Saúde de Manhiça;ICREA;Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Sant Joan de Déu ,(University of Barcelona);Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública;Neuroscience Research Group, Department of Clinical Sciences;Institute of Human Development, Aga Khan University;Neonatology Department, Christian Medical College;Fundación INFANT;National Technical and Scientific Research Council;Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand;Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand;Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand;Department of Psychiatry, Medical Sciences Division, University of Oxford;Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research

关键词: Group B streptococcus;    meningitis;    sepsis;    infants;    children;    impairment;    neurodevelopment;    disability;    economic;    cost;   

DOI  :  10.12688/gatesopenres.13185.2

学科分类：电子与电气工程

来源: American Journal Of Pharmtech Research

【 摘 要 】

Sepsis and meningitis due to invasive group B Streptococcus (iGBS) disease during early infancy is a leading cause of child mortality. Recent systematic estimates of the worldwide burden of GBS suggested that there are 319,000 cases of infant iGBS disease each year, and an estimated 147,000 stillbirths and young-infant deaths, with the highest burden occurring in Sub-Saharan Africa.  The following priority data gaps were highlighted: (1) long-term outcome data after infant iGBS, including mild disability, to calculate quality-adjusted life years (QALYs) or disability-adjusted life years (DALYs) and (2) economic burden for iGBS survivors and their families. Geographic data gaps were also noted with few studies from low- and middle- income countries (LMIC), where the GBS burden is estimated to be the highest. In this paper we present the protocol for a multi-country matched cohort study designed to estimate the risk of long-term neurodevelopmental impairment (NDI), socioemotional behaviors, and economic outcomes for children who survive invasive GBS disease in Argentina, India, Kenya, Mozambique, and South Africa. Children will be identified from health demographic surveillance systems, hospital records, and among participants of previous epidemiological studies. The children will be aged between 18 months to 17 years. A tablet-based custom-designed application will be used to capture data from direct assessment of the child and interviews with the main caregiver. In addition, a parallel sub-study will prospectively measure the acute costs of hospitalization due to neonatal sepsis or meningitis, irrespective of underlying etiology. In summary, these data are necessary to characterize the consequences of iGBS disease and enable the advancement of effective strategies for survivors to reach their developmental and economic potential. In particular, our study will inform the development of a full public health value proposition on maternal GBS immunization that is being coordinated by the World Health Organization.

【 授权许可】

CC BY