Risk factors for unplanned reoperation after corrective surgery for adult spinal deformity: machine learning-based game theoretic approach

Bone & Joint Research

article

Seung-Jun Ryu¹  Jae-Young So¹  Yoon Ha²  Sung-Uk Kuh²  Dong-Kyu Chin³  Keun-Su Kim³  Yong-Eun Cho³  Kyung-Hyun Kim³ 

[1] Department of Neurosurgery, National Health Insurance Service Ilsan Hospital;Department of Neurosurgery, The Spine and Spinal Cord Institute, Severance Hospital, Yonsei University College of Medicine;Department of Neurosurgery, The Spine and Spinal Cord Institute, Gangnam Severance Hospital, Yonsei University College of Medicine

关键词: Unplanned reoperation;    Game theory;    Adult spinal deformity;    adult spinal deformity (ASD);    revision surgery;    Kaplan-Meier survival analysis;    diagnostic radiology;    t-tests;    T1 slope;    sagittal vertical axis;    osteotomies;    bone mineral density;    spine;   

DOI  :  10.1302/2046-3758.124.BJR-2022-0121.R1

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

AimsTo determine the major risk factors for unplanned reoperations (UROs) following corrective surgery for adult spinal deformity (ASD) and their interactions, using machine learning-based prediction algorithms and game theory.MethodsPatients who underwent surgery for ASD, with a minimum of two-year follow-up, were retrospectively reviewed. In total, 210 patients were included and randomly allocated into training (70% of the sample size) and test (the remaining 30%) sets to develop the machine learning algorithm. Risk factors were included in the analysis, along with clinical characteristics and parameters acquired through diagnostic radiology.ResultsOverall, 152 patients without and 58 with a history of surgical revision following surgery for ASD were observed; the mean age was 68.9 years (SD 8.7) and 66.9 years (SD 6.6), respectively. On implementing a random forest model, the classification of URO events resulted in a balanced accuracy of 86.8%. Among machine learning-extracted risk factors, URO, proximal junction failure (PJF), and postoperative distance from the posterosuperior corner of C7 and the vertical axis from the centroid of C2 (SVA) were significant upon Kaplan-Meier survival analysis.ConclusionThe major risk factors for URO following surgery for ASD, i.e. postoperative SVA and PJF, and their interactions were identified using a machine learning algorithm and game theory. Clinical benefits will depend on patient risk profiles.

【 授权许可】

CC BY-NC