What is the appropriate extended duration of antibiotic prophylaxis after two-stage revision for chronic PJI?

Bone & Joint Research

article

Xinyu Fang¹  Qiaojie Wang²  Xurong Yang³  Feiyang Zhang²  Changyu Huang¹  Zida Huang¹  Hao Shen²  Wenming Zhang¹ 

[1] Department of Orthopaedic Surgery, The First Affiliated Hospital of Fujian Medical University;Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital;Department of Orthopaedic Surgery, Jiangle County General Hospital

关键词: Periprosthetic joint infection;    Stage II reimplantation;    Course of antibiotics;    antibiotics prophylaxis;    Periprosthetic joint infection (PJI);    antibiotics;    infections;    reimplantation surgery;    prognosis;    Cox regression analysis;    t-test;    chi-squared test;    hip and knee arthroplasty;   

DOI  :  10.1302/2046-3758.1012.BJR-2021-0225.R1

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

AimsTo explore the effect of different durations of antibiotics after stage II reimplantation on the prognosis of two-stage revision for chronic periprosthetic joint infection (PJI).Methodsone month) course of treatment based on the duration of antibiotics following stage II reimplantation. The difference in the infection control rate between the two groups was compared, and prognostic factors for recurrence were analyzed.ResultsA total of 105 patients with chronic PJI were enrolled: 64 patients in the short course group and 41 patients in the long course group. For 99 of the patients, the infection was under control during a follow-up period of at least 24 months after two-stage revision. For the short course group, the mean duration of antibiotic prophylaxis after stage II reimplantation was 20.17 days (SD 5.30) and the infection control rate was 95.3%; for the long course group these were 45.02 days (SD 15.03) and 92.7%, respectively. There was no significant difference in infection control rates between the two groups (p = 0.676). Cox regression analysis found that methicillin-resistant staphylococcus infection (p = 0.015) was an independent prognostic factor for recurrence.ConclusionAfter stage II reimplantation surgery of two-stage revision for chronic PJI, extended antibiotic prophylaxis for less than one month can achieve good infection control rate.

【 授权许可】

CC BY-NC