Signalling and putative therapeutic molecules on the regulation of synoviocyte signalling in rheumatoid arthritis

Bone & Joint Research

article

Minjeong Ji¹  Hee Jung Ryu²  Jeong Hee Hong¹ 

[1] Department of Physiology, College of Medicine, Gachon University, Lee Gil Ya Cancer and Diabetes Institute, Incheon;Department of Rheumatology, Gachon University Gil Medical Center, Incheon

关键词: Rheumatoid arthritis;    Synoviocytes;    Inflammation;    Hyperplasia;    Joint destruction;   

DOI  :  10.1302/2046-3758.104.BJR-2020-0331.R1

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetrical and chronic polyarthritis. Fibroblast-like synoviocytes are mainly involved in joint inflammation and cartilage and bone destruction by inflammatory cytokines and matrix-degrading enzymes in RA. Approaches that induce various cellular growth alterations of synoviocytes are considered as potential strategies for treating RA. However, since synoviocytes play a critical role in RA, the mechanism and hyperplastic modulation of synoviocytes and their motility need to be addressed. In this review, we focus on the alteration of synoviocyte signalling and cell fate provided by signalling proteins, various antioxidant molecules, enzymes, compounds, clinical candidates, to understand the pathology of the synoviocytes, and finally to achieve developed therapeutic strategies of RA.

【 授权许可】

CC BY-NC