Bone mineral as a drug-seeking moiety and a waste dump: a review

Bone & Joint Research

article

Deepak Bushan Raina¹  Yang Liu¹  Otto L. P. Jacobson¹  K Elizabeth Tanner²  Magnus Tägil¹  Lars Lidgren¹ 

[1] Lund University;School of Engineering and Materials Science and Institute of Bioengineering, Queen Mary University of London

关键词: Hydroxyapatite;    Bone infection;    Antibiotics;    Bone mineral;    Waste dump;   

DOI  :  10.1302/2046-3758.910.BJR-2020-0097.R1

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the material and lead to a therapeutic effect. Bone mineral and apatite however also act as a waste dump for trace elements and drugs, which significantly affects the environment and human health.

【 授权许可】

CC BY-NC