Can lessons learned about preventing cardiac muscle death be applied to prevent skeletal muscle death?

Bone & Joint Research

article

Daniel B. Buchalter¹  David J. Kirby¹  Kenneth A. Egol¹  Philipp Leucht¹  Sanjit R. Konda¹ 

[1] NYU Langone Orthopedic Hospital

关键词: Glucose-insulin-potassium;    Skeletal muscle;    Ischaemia-reperfusion;   

DOI  :  10.1302/2046-3758.96.BJR-2019-0241.R1

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

In 2017, 200 million people worldwide wereliving with disability due to fractures.1 Softtissue damage and prolonged tourniquetapplication as a result of these injuries canlead to limb dysfunction, paralysis, and evenamputation.2 While ischaemia often causes theinitial insult, reperfusion leads to a second-hit,intense inflammatory response that can causemuscle apoptosis and necrosis in what hasbeen termed the ischaemia-reperfusion (IR)injury.3 Other causes of skeletal muscle IR injuryinclude elective or emergent tourniquet use,acute or chronic compartment syndrome, andvascular injury requiring repair.4 PreventingIR injury has been an area of interest in cardiology after myocardial infarction (MI) but hasnot been aggressively pursued in the orthopaedic realm.

【 授权许可】

CC BY-NC