Mechanotransduction in osteogenesis

Bone & Joint Research

article

Sarah Stewart¹  Alastair Darwood¹  Spyros Masouros¹  Claire Higgins¹  Arul Ramasamy¹ 

[1] Imperial College London

关键词: Mechanotransduction;    Mechanoreceptor;    Bone;   

DOI  :  10.1302/2046-3758.91.BJR-2019-0043.R2

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

Bone is one of the most highly adaptive tissues in the body, possessing the capability to alter its morphology and function in response to stimuli in its surrounding environment. The ability of bone to sense and convert external mechanical stimuli into a biochemical response, which ultimately alters the phenotype and function of the cell, is described as mechanotransduction. This review aims to describe the fundamental physiology and biomechanisms that occur to induce osteogenic adaptation of a cell following application of a physical stimulus. Considerable developments have been made in recent years in our understanding of how cells orchestrate this complex interplay of processes, and have become the focus of research in osteogenesis. We will discuss current areas of preclinical and clinical research exploring the harnessing of mechanotransductive properties of cells and applying them therapeutically, both in the context of fracture healing and de novo bone formation in situations such as nonunion.

【 授权许可】

CC BY-NC