Tissue engineering strategies for the treatment of tendon injuries: a systematic review and meta-analysis of animal models

Bone & Joint Research

article

D. González-Quevedo¹  I. Martínez-Medina¹  A. Campos³  F. Campos³  V. Carriel³ 

[1] Department of Orthopedic Surgery and Traumatology, Regional University Hospital of Málaga;PhD Program in Biomedicine, University of Granada;Department of Histology ,(Tissue Engineering Group) and Instituto de Investigación Biosanitaria Ibs University of Granada

关键词: Tissue engineering;    Tendon injury;    Cell-based therapies;    Tendon healing;    Biomaterials;    Review;   

DOI  :  10.1302/2046-3758.74.BJR-2017-0326

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

ObjectivesRecently, the field of tissue engineering has made numerous advances towards achieving artificial tendon substitutes with excellent mechanical and histological properties, and has had some promising experimental results. The purpose of this systematic review is to assess the efficacy of tissue engineering in the treatment of tendon injuries.MethodsWe searched MEDLINE, Embase, and the Cochrane Library for the time period 1999 to 2016 for trials investigating tissue engineering used to improve tendon healing in animal models. The studies were screened for inclusion based on randomization, controls, and reported measurable outcomes. The RevMan software package was used for the meta-analysis.ResultsA total of 388 references were retrieved and 35 studies were included in this systematic review. The different biomaterials developed were analyzed and we found that they improve the biomechanical and histological characteristics of the repaired tendon. At meta-analysis, despite a high heterogeneity, it revealed a statistically significant effect in favour of the maximum load, the maximum stress, and the Young’s modulus between experimental and control groups. In the forest plot, the diamond was on the right side of the vertical line and did not intersect with the line, favouring experimental groups.ConclusionsThis review of the literature demonstrates the heterogeneity in the tendon tissue engineering literature. Several biomaterials have been developed and have been shown to enhance tendon healing and regeneration with improved outcomes.

【 授权许可】

CC BY-NC