PeerJ | |
PKC in motorneurons underlies self-learning, a form of motor learning in Drosophila | |
article | |
Julien Colomb1  Björn Brembs1  | |
[1] Biologie, Chemie, Pharmazie, Institut für Biologie-Neurobiologie, Freie Universität Berlin;Institute of Zoology—Neurogenetics, Universität Regensburg | |
关键词: Motor learning; Habit; Operant learning; FoxP; Skill learning; Procedural memory; Motor adaptation; Egocentric strategy; | |
DOI : 10.7717/peerj.1971 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Inra | |
【 摘 要 】
Tethering a fly for stationary flight allows for exquisite control of its sensory input, such as visual or olfactory stimuli or a punishing infrared laser beam. A torque meter measures the turning attempts of the tethered fly around its vertical body axis. By punishing, say, left turning attempts (in a homogeneous environment), one can train a fly to restrict its behaviour to right turning attempts. It was recently discovered that this form of operant conditioning (called operant self-learning), may constitute a form of motor learning in Drosophila. Previous work had shown that Protein Kinase C (PKC) and the transcription factor dFoxP were specifically involved in self-learning, but not in other forms of learning. These molecules are specifically involved in various forms of motor learning in other animals, such as compulsive biting in Aplysia, song-learning in birds, procedural learning in mice or language acquisition in humans. Here we describe our efforts to decipher which PKC gene is involved in self-learning in Drosophila. We also provide evidence that motorneurons may be one part of the neuronal network modified during self-learning experiments. The collected evidence is reminiscent of one of the simplest, clinically relevant forms of motor learning in humans, operant reflex conditioning, which also relies on motorneuron plasticity.
【 授权许可】
CC BY
【 预 览 】
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RO202307100015340ZK.pdf | 352KB | download |