Association between the HTR2C rs1414334 C/G gene polymorphism and the development of the metabolic syndrome in patients treated with atypical antipsychotics

PeerJ

article

José María Rico-Gomis¹  Antonio Palazón-Bru¹  Irene Triano-García⁴  Luis Fabián Mahecha-García²  Ana García-Monsalve⁴  Andrés Navarro-Ruiz⁴  Berta Villagordo-Peñalver²  Jessica Jiménez-Abril²  Alicia Martínez-Hortelano²  Vicente Francisco Gil-Guillén¹ 

[1] Department of Clinical Medicine, Miguel Hernández University;Department of Psychiatry, General University Hospital of Elche;Research Unit, General University Hospital of Elda;Pharmacy Service, General University Hospital of Elche

关键词: HTR2C;    Psychotic disorders;    Antipsychotic agents;    Pharmacogenetics;    Metabolic syndrome X;   

DOI  :  10.7717/peerj.2163

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Few studies have assessed the association between the rs1414334 C/G polymorphism in the HTR2C gene and the development of the metabolic syndrome in patients treated with atypical antipsychotics. To provide further evidence, a cross-sectional study was conducted in Spain between 2012 and 2013 in 166 patients with these characteristics. In these patients, the association between the polymorphism and the presence of the metabolic syndrome was determined by implementing binary logistic regression models adjusted for variables associated with the metabolic syndrome. We did not confirm previous claims that the C allele of the polymorphism was linked to the metabolic syndrome: the association was in the opposite direction and non-significant. This conclusion held after taking gender and lifestyle variables into account.

【 授权许可】

CC BY