Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose

PeerJ

article

Wilasinee Suwanjang¹  Supaluk Prachayasittikul²  Virapong Prachayasittikul³ 

[1] Center for Research and Innovation, Faculty of Medical Technology, Mahidol University;Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University;Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University

关键词: Calpain;    Nitroxoline;    8-Hydroxyquinoline;    High glucose;    Clioquinol;    Neuronal cells;   

DOI  :  10.7717/peerj.2389

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

8-Hydroxyquinoline and derivatives exhibit multifunctional properties, including antioxidant, antineurodegenerative, anticancer, anti-inflammatory and antidiabetic activities. In biological systems, elevation of intracellular calcium can cause calpain activation, leading to cell death. Here, the effect of 8-hydroxyquinoline and derivatives (5-chloro-7-iodo-8-hydroxyquinoline or clioquinol and 8-hydroxy-5-nitroquinoline or nitroxoline) on calpain-dependent (calpain-calpastatin) pathways in human neuroblastoma (SH-SY5Y) cells was investigated. 8-Hydroxyquinoline and derivatives ameliorated high glucose toxicity in SH-SY5Y cells. The investigated compounds, particularly clioquinol, attenuated the increased expression of calpain, even under high-glucose conditions. 8-Hydroxyquinoline and derivatives thus adversely affected the promotion of neuronal cell death by high glucose via the calpain-calpastatin signaling pathways. These findings support the beneficial effects of 8-hydroxyquinolines for further therapeutic development.

【 授权许可】

CC BY