One-year mortality after severe COPD exacerbation in Bulgaria

PeerJ

article

Evgeni Mekov¹  Yanina Slavova¹  Adelina Tsakova²  Marianka P. Genova²  Dimitar T. Kostadinov¹  Delcho Minchev¹  Dora Marinova¹  Mihail A. Boyanov³ 

[1] Clinical Center for Pulmonary Diseases, Medical University—Sofia;Department of Clinical Laboratory and Clinical Immunology, Central Clinical Laboratory, Medical University—Sofia, University Hospital “Alexandrovska;Department of Internal Medicine, Clinic of Endocrinology and Metabolism, Medical University—Sofia, University Hospital “Alexandrovska

关键词: COPD;    Exacerbation;    Mortality;    Lung function;    Quality of life;    Comorbidities;   

DOI  :  10.7717/peerj.2788

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

IntroductionOne-year mortality in COPD patients is reported to be between 4% and 43%, depending on the group examined.AimTo examine the one-year mortality in COPD patients after severe exacerbation and the correlation between mortality and patients’ characteristics and comorbidities.MethodsA total of 152 COPD patients hospitalized for severe exacerbation were assessed for vitamin D status, diabetes mellitus (DM), arterial hypertension (AH), and metabolic syndrome (MS). Data were gathered about smoking status and number of exacerbations in previous year. CAT and mMRC questionnaires were completed by all patients. Pre- and post-bronchodilatory spirometry was performed. One-year mortality was established from national death register.ResultsOne-year mortality is 7.2%. DM, MS, and VD are not predictors for one-year mortality. However there is a trend for increased mortality in patients with AH (9.5% vs. 2.1%, p 2 (11.1 vs. 0%, p = 0.013). The presence of severe exacerbation in the previous year is a risk factor for mortality (12.5% vs. 1.4%, p = 0.009). There is a trend for increased mortality in the group with FEV1 < 50% (11.5 vs. 4.4%, p = 0.094). Cox regression shows 3.7% increase in mortality rate for 1% decrease in FEV1, 5.2% for 1% decrease in PEF, 7.8% for one year age increase and 8.1% for 1 CAT point increase (all p < 0.05).Conclusions 80% may be factors for good prognosis. Risk factors for increased mortality are age, FEV1 value, severe exacerbation in previous year and reduced quality of life.

【 授权许可】

CC BY