Potential wound healing activity of Quercus infectoria formulation in diabetic rats

PeerJ

article

Julalak Chokpaisarn¹  Sasitorn Chusri²  Thanaporn Amnuaikit³  Wandee Udomuksorn⁴  Supayang Piyawan Voravuthikunchai¹ 

[1] Department of Microbiology and Excellence Research Laboratory of Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University;Faculty of Traditional Thai Medicine and Excellence Research Laboratory on Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University;Department of Pharmaceutical Technology and Excellence Research Laboratory on Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Faculty of Pharmaceutical Sciences, Prince of Songkla University;Department of Pharmacology, Faculty of Science, Prince of Songkla University

关键词: Diabetic wounds;    Quercus infectoria;    Wound healing process;    Wound treatment;   

DOI  :  10.7717/peerj.3608

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundQuercus infectoria G. Olivier (Fagaceae) nutgalls have been widely employed in traditional Asian medicine for several treatments, especially wounds and skin disorders. However, the effects of this plant on wound healing have not yet been clearly elucidated. This present work was focused on utilization of Quercus infectoria (Qi) as a topical agent for chronic wound treatment.MethodsTwenty Qi formulations (QiFs) were pharmaceutically formulated and antibacterial activity of all formulations was performed. The best formulation based on an antibacterial activity was selected for evaluation of wound healing property. Total phenolics, total flavonoids, and an anti-oxidant activity of the selected formulation were also investigated. Wound healing activity was assessed in streptozotocin-induced diabetic rats and control rats. Streptozotocin injection (50 mg/kg) was found to induce marked hyperglycaemia, compared with citrate-injected controls. Two wounds were created on the upper back of each animal. QiF was topically applied three days after wounding to one of the duplicate wounds on each animal and physiological saline (control) was applied to the other. All wounds were cleaned once a day until wound closure.ResultsQiF10, which exhibited antibacterial and anti-oxidant activities, had the ability to enhance the wound healing process in diabetic rats with abundant cellular infiltration, collagen deposition, and re-epithelialization when compared with the control.DiscussionThis study suggested that QiF10 could be a novel alternative treatment for diabetic wounds.

【 授权许可】

CC BY