期刊论文详细信息
PeerJ
Augmented cartilage regeneration by implantation of cellular versus acellular implants after bone marrow stimulation: a systematic review and meta-analysis of animal studies
article
Michiel W. Pot1  Toin H. van Kuppevelt1  Veronica K. Gonzales2  Pieter Buma2  Joanna IntHout3  Rob B.M. de Vries4  Willeke F. Daamen1 
[1] Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud university medical center;Department of Orthopedics, Radboud Institute for Molecular Life Sciences, Radboud university medical center;Department for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center;SYRCLE ,(SYstematic Review Centre for Laboratory animal Experimentation), Central Animal Laboratory, Radboud university medical center
关键词: Cartilage;    Biomaterials;    Regenerative medicine;    Cells;    Microfracture;   
DOI  :  10.7717/peerj.3927
学科分类:社会科学、人文和艺术(综合)
来源: Inra
PDF
【 摘 要 】

Bone marrow stimulation may be applied to regenerate focal cartilage defects, but generally results in transient clinical improvement and formation of fibrocartilage rather than hyaline cartilage. Tissue engineering and regenerative medicine strive to develop new solutions to regenerate hyaline cartilage tissue. This systematic review and meta-analysis provides a comprehensive overview of current literature and assesses the efficacy of articular cartilage regeneration by implantation of cell-laden versus cell-free biomaterials in the knee and ankle joint in animals after bone marrow stimulation. PubMed and EMBASE (via OvidSP) were systematically searched using tissue engineering, cartilage and animals search strategies. Included were primary studies in which cellular and acellular biomaterials were implanted after applying bone marrow stimulation in the knee or ankle joint in healthy animals. Study characteristics were tabulated and outcome data were collected for meta-analysis for studies applying semi-quantitative histology as outcome measure (117 studies). Cartilage regeneration was expressed on an absolute 0–100% scale and random effects meta-analyses were performed. Implantation of cellular biomaterials significantly improved cartilage regeneration by 18.6% compared to acellular biomaterials. No significant differences were found between biomaterials loaded with stem cells and those loaded with somatic cells. Culture conditions of cells did not affect cartilage regeneration. Cartilage formation was reduced with adipose-derived stem cells compared to other cell types, but still improved compared to acellular scaffolds. Assessment of the risk of bias was impaired due to incomplete reporting for most studies. Implantation of cellular biomaterials improves cartilage regeneration compared to acellular biomaterials.

【 授权许可】

CC BY   

【 预 览 】
附件列表
Files Size Format View
RO202307100013357ZK.pdf 560KB PDF download
  文献评价指标  
  下载次数:7次 浏览次数:1次