Increased risk of periodontitis in patients with psoriatic disease: a nationwide population-based retrospective cohort study

PeerJ

article

Ni-Yu Su¹  Jing-Yang Huang³  Chien-Jen Hu²  Hui-Chieh Yu²  Yu-Chao Chang¹ 

[1] Department of Periodontics, Chung Shan Medical University Hospital;School of Dentistry, Chung Shan Medical University;Department of Medical Research, Chung Shan Medical University Hospital

关键词: Psoriasis;    Periodontitis;    Psoriatic arthritis;    Nationwide population;    Cohort study;   

DOI  :  10.7717/peerj.4064

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

AimsPeriodontitis and psoriatic disease, including psoriasis (PS) and psoriatic arthritis (PsA), share the common risk factors and co-morbidities. However, the risk of periodontitis in patients with psoriatic disease still needs further investigation. This study was a nationwide population-based retrospective cohort study assessing the risk of periodontitis from psoriatic disease exposure.Materials and MethodsPatients with newly diagnosed psoriatic disease from 2003 to 2012 were identified from the Taiwanese National Health Insurance Research Database. The 1:4 ratio propensity score matched controls were selected from no psoriatic disease participations. The subsequent risk of periodontitis was evaluated in exposure and comparison groups. Multiple Cox proportional hazard models were used for the estimation.ResultsA total of 3,487 psoriatic disease patients and 13,948 controls were identified. Incidence rate of periodontitis was higher in patients with PsA. The adjusted hazard ratio (aHRs) for moderate/severe periodontitis were 0.85 (95% CI [0.65–1.11]) in PS group and 1.66 (95% CI [0.99–2.78]) in PsA group. The aHRs of PsA were increased over time, aHRs was changed from 0.65 (0–11 months from index date) to 1.34 (≥12 months from index date) in all types of periodontitis and from 1.09 to 1.79 in moderate/severe periodontitis group, respectively.ConclusionsThe increased risk of periodontitis was observed, especially the association between PsA and moderate/severe periodontitis. The patients with psoriatic disease should receive regular periodontal evaluation.

【 授权许可】

CC BY