Arbutin increases Caenorhabditis elegans longevity and stress resistance

PeerJ

article

Lin Zhou¹  Xueqi Fu¹  Liyan Jiang¹  Lu Wang¹  Shuju Bai¹  Yan Jiao¹  Shu Xing¹  Wannan Li¹  Junfeng Ma¹ 

[1] School of Life Sciences, Jilin University, Changchun, Jilin Province

关键词: Arbutin;    C. elegans;    daf-16;    Stress;    Longevity;   

DOI  :  10.7717/peerj.4170

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Arbutin (p-hydroxyphenyl-β-D-glucopyranoside), a well-known tyrosinase inhibitor, has been widely used as a cosmetic whitening agent. Although its natural role is to scavenge free radicals within cells, it has also exhibited useful activities for the treatment of diuresis, bacterial infections and cancer, as well as anti-inflammatory and anti-tussive activities. Because function of free radical scavenging is also related to antioxidant and the effects of arbutin on longevity and stress resistance in animals have not yet been confirmed, here the effects of arbutin on Caenorhabditis elegans were investigated. The results demonstrated that optimal concentrations of arbutin could extend lifespan and enhance resistance to oxidative stress. The underlying molecular mechanism for these effects involves decreased levels of reactive oxygen species (ROS), improvement of daf-16 nuclear localization, and up-regulated expression of daf-16 and its downstream targets, including sod-3 and hsp16.2. In this work the roles of arbutin in lifespan and health are studied and the results support that arbutin is an antioxidant for maintaining overall health.

【 授权许可】

CC BY