The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study

PeerJ

article

Diankun Liu¹  Ting Huang¹  Nan Chen²  Gang Xu³  Ping Zhang⁴  Yang Luo⁵  Yongping Wang¹  Tao Lu¹  Long Wang¹  Mengqi Xiong¹  Jian Geng⁶  Sheng Nie¹ 

[1] The National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University;Ruijin Hospital, Shanghai Jiao Tong University;Tongji Hospital, Huazhong University of Science and Technology;Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Science;Beijing Shijitan Hospital, Capital Medical University;King Medical Diagnostics Center;School of Basic Medical Sciences, Southern Medical University

关键词: Renal biopsy;    Diabetic nephropathy;    Non-diabetic renal disease;    Diabetes mellitus;    Membranous nephropathy;   

DOI  :  10.7717/peerj.4522

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundRenal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking.MethodsIn a nationwide renal biopsy survey including 71,151 native biopsies from 2004 to 2014, diabetic patients were identified according to the clinical diagnosis from referral records. The clinical data were extracted from referral records and pathological reports.ResultsA total of 1,604 diabetic patients, including 61 patients with T1DM, were analyzed in this study. The median age is 51.39 ± 11.37 years. Male patients accounted for 58% of the population. We found that only 44.7% of diabetic patients had the isolated pathological diagnosis of diabetic nephropathy (DN), while 49.1% had non-diabetic renal disease (NDRD) alone, and 6.2% had NDRD superimposed on DN. Nephrotic syndrome (n = 824, 51.4%) was the most common clinical indication for renal biopsy. Among 887 patients with NDRD, membranous nephropathy (n = 357) was the leading diagnosis, followed by IgA nephropathy (n = 179). Hypertensive renal disease (n = 32), tubulointerstitial nephropathy (n = 27) and acute tubular necrosis (n = 16) accounted for 3.5%, 2.9%, 1.7% of the NDRD cases respectively. Nearly a half (49.2%) of patients with T1DM had NDRD.DiscussionOver 55% diabetic patients with kidney disease were diagnosed as non-diabetic renal disease, among which MN and IgAN were the most common two pathological types.

【 授权许可】

CC BY