Loss anticipation and outcome during the Monetary Incentive Delay Task : a neuroimaging systematic review and meta-analysis

PeerJ

article

Jules R. Dugré¹  Alexandre Dumais¹  Nathalie Bitar¹  Stéphane Potvin¹ 

[1] Department of Psychiatry, University of Montreal;Centre de recherche de l’Institut Universitaire en Santé Mentale de Montréal;Institut Philippe-Pinel de Montréal

关键词: Monetary Incentive Delay Task;    Meta-analysis;    fMRI;    Punishment;    Loss avoidance;   

DOI  :  10.7717/peerj.4749

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundReward seeking and avoidance of punishment are key motivational processes. Brain-imaging studies often use the Monetary Incentive Delay Task (MIDT) to evaluate motivational processes involved in maladaptive behavior. Although the bulk of research has been done on the MIDT reward events, little is known about the neural basis of avoidance of punishment. Therefore, we conducted a meta-analysis of brain activations during anticipation and receipt of monetary losses in healthy controls.MethodsAll functional neuro-imaging studies using the MIDT in healthy controls were retrieved using PubMed, Google Scholar & EMBASE databases. Functional neuro-imaging data was analyzed using the Seed-based d Mapping Software.ResultsNeutral contrast. Although relatively similar activation patterns were observed during the two event types, they differed in the pattern of prefrontal activations: ventro-lateral prefrontal activations were observed during loss anticipation, while medial prefrontal activations were observed during loss receipt.DiscussionConsidering that previous meta-analyses highlighted activations in the medial prefrontal cortex/anterior cingulate cortex, the anterior insula and the ventral striatum, the current meta-analysis highlighted the potential specificity of the ventro-lateral prefrontal regions, the median cingulate cortex and the amygdala in the loss events. Future studies can rely on these latter results to examine the neural correlates of loss processing in psychiatric populations characterized by harm avoidance or insensitivity to punishment.

【 授权许可】

CC BY