Intolerance of uncertainty and conditioned place preference in opioid addiction

PeerJ

article

Milen L. Radell¹  Michael Todd Allen²  Belinda Favaloro³  Catherine E. Myers⁴  Paul Haber⁶  Kirsten Morley⁶  Ahmed A. Moustafa³ 

[1]Department of Psychology, Niagara University

[2]School of Psychological Sciences, University of Northern Colorado

[3]School of Social Sciences and Psychology, Western Sydney University

[4]Department of Veterans Affairs New Jersey Health Care System

[5]Department of Pharmacology, Physiology & Neuroscience, New Jersey Medical School, Rutgers University

[6]Discipline of Addiction Medicine, Central Clinical School, The University of Sydney

[7]Marcs Institute for Brain, Behaviour and Development, Western Sydney University

关键词: Addiction;    Decision making;    Conditioned place preference;    Intolerance of uncertainty;   

DOI  :  10.7717/peerj.4775

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Several personality factors have been implicated in vulnerability to addiction by impacting learning and decision making. One such factor is intolerance of uncertainty (IU), the tendency to perceive uncertain situations negatively and avoid them. Conditioned place preference (CPP), which compares preference for contexts paired with reward, has been used to examine the motivation for both drug and non-drug rewards. However, preference for locations associated with non-drug reward, as well as the potential influence of IU, has not been thoroughly studied in individuals with addiction. In the current study, we examined CPP using a computer-based task in a sample of addicted individuals undergoing opioid maintenance treatment and never-addicted controls. Patients were confirmed to have higher IU than controls. In the CPP task, the two groups did not differ in overall time spent in the previously-rewarded context. However, controls were more likely than patients to immediately return to this context. Contrary to our predictions, IU was not a significant predictor of preference for the previously-rewarded context, although higher IU in controls was associated with a higher number of rewards obtained in the task. No such relationship was found in patients.

【 授权许可】

CC BY