Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles

PeerJ

article

Lenka Urbankova¹  Pavel Horky¹  Jiri Skladanka¹  Magdalena Pribilova¹  Vendula Smolikova²  Pavel Nevrkla⁴  Natalia Cernei²  Zuzana Lackova²  Josef Hedbavny²  Andrea Ridoskova²  Vojtech Adam²  Pavel Kopel² 

[1] Department of Animal Nutrition and Forage Production, Faculty of AgriSciences, Mendel University in Brno;Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno;Central European Institute of Technology, Technical University of Brno;Department of Animal Breeding, Faculty of AgriSciences, Mendel University in Brno

关键词: Selenium nanoparticles;    Glutathione;    Rat;    Animal nutrition;    Antioxidant;   

DOI  :  10.7717/peerj.4862

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background Selenium is an essential element; however, at higher doses, it can be toxic. Therefore, alternative nanotechnological solutions are required to overcome toxicological issues, rather than conventional alternatives. Nanoparticles show new and promising properties that may be able to suppress toxicity while maintaining the positive effects of selenium on an organism. The aim of the experiment was to determine the influence of sodium selenite and selenium nanoparticles (SeNPs) on the antioxidant status of rats. Methods The males of the outbreed rat strain Wistar albino were selected as a model organism. Animals were fed different forms of selenium. The control group was given a mixture without selenium addition, whereas other groups were fed a mixture containing sodium selenite, Se-49, and Se-100 SeNPs respectively. The duration of the trial was 30 days. Results Analysis of blood and liver was performed where the concentration of reduced (GSH) and oxidised (GSSG) glutathione, and total selenium content were measured. In the liver, a significant reduction in GSSG was found for all experiment groups. Blood samples showed a significant reduction in GSH and an increase in GSSG. Discussion These results show that SeNPs may be an alternative to dietary selenium for animal organisms.

【 授权许可】

CC BY