Modeling and analysis of the impacts of jet lag on circadian rhythm and its role in tumor growth

PeerJ

article

Azka Hassan¹  Jamil Ahmad¹  Hufsah Ashraf¹  Amjad Ali² 

[1] Research Center for Modeling and Simulation ,(RCMS), National University of Scinces and Technology;Atta-ur-Rahman School of Applied Biosciences ,(ASAB), National University of Science and Technology

关键词: Circadian clock;    Jet lag;    Tumor progression;    Model checking;    Petri net;    Qualitative modeling;   

DOI  :  10.7717/peerj.4877

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Circadian rhythms maintain a 24 h oscillation pattern in metabolic, physiological and behavioral processes in all living organisms. Circadian rhythms are organized as biochemical networks located in hypothalamus and peripheral tissues. Rhythmicity in the expression of circadian clock genes plays a vital role in regulating the process of cell division and DNA damage control. The oncogenic protein, MYC and the tumor suppressor, p53 are directly influenced by the circadian clock. Jet lag and altered sleep/wake schedules prominently affect the expression of molecular clock genes. This study is focused on developing a Petri net model to analyze the impacts of long term jet lag on the circadian clock and its probable role in tumor progression. The results depict that jet lag disrupts the normal rhythmic behavior and expression of the circadian clock proteins. This disruption leads to persistent expression of MYC and suppressed expression of p53. Thus, it is inferred that jet lag altered circadian clock negatively affects the expressions of cell cycle regulatory genes and contribute in uncontrolled proliferation of tumor cells.

【 授权许可】

CC BY