In vitro activities of antifungals alone and in combination with tigecycline against Candida albicans biofilms

PeerJ

article

Mayram Hacioglu¹  Ayse Seher Birteksoz Tan¹  Sibel Dosler¹  Nese Inan²  Gulten Otuk¹ 

[1] Department of Pharmaceutical Microbiology, Istanbul University;Department of Microbiology, Faculty of Medicine, Istanbul Bilim University

关键词: Biofilm;    Antifungal;    Tigecycline;    XTT;    Candida albicans;   

DOI  :  10.7717/peerj.5263

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundCandida may form biofilms, which are thought to underlie the most recalcitrant infections.MethodsIn this study, activities of antifungal agents alone and in combination with tigecycline against planktonic cells and mature and developing biofilms of Candida albicans isolates were evaluated.ResultsAmphotericin B and echinocandins were found to be the most effective agents against mature biofilms, whereas the least effective agent was fluconazole. Furthermore, the most effective anti-fungal monotherapies against biofilm formation were amphotericin B and anidulafungin, and the least effective monotherapy was itraconazole. The combination of tigecycline and amphotericin B yielded synergistic effects, whereas combinations containing itraconazole yielded antagonist effects against planktonic cells. The combination of tigecycline and caspofungin exhibited maximum efficacy against mature biofilms, whereas combinations containing itraconazole exhibited minimal effects. Combinations of tigecycline with amphotericin B or anidulafungin were highly effective against C. albicans biofilm formation.DiscussionIn summary, tigecycline was highly active against C. albicans particularly when combined with amphotericin B and echinocandins.

【 授权许可】

CC BY