CMTCN: a web tool for investigating cancer-specific microRNA and transcription factor co-regulatory networks

PeerJ

article

Ruijiang Li¹  Hebing Chen¹  Shuai Jiang¹  Wanying Li¹  Hao Li¹  Zhuo Zhang¹  Hao Hong¹  Xin Huang¹  Chenghui Zhao¹  Yiming Lu¹  Xiaochen Bo¹ 

[1] Department of Biotechnology, Beijing Institute of Radiation Medicine

关键词: MicroRNA;    Transcription factor;    Co-regulation;    Network;    Cancer;    Web tool;   

DOI  :  10.7717/peerj.5951

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Transcription factors (TFs) and microRNAs (miRNAs) are well-characterized trans-acting essential players in gene expression regulation. Growing evidence indicates that TFs and miRNAs can work cooperatively, and their dysregulation has been associated with many diseases including cancer. A unified picture of regulatory interactions of these regulators and their joint target genes would shed light on cancer studies. Although online resources developed to support probing of TF-gene and miRNA-gene interactions are available, online applications for miRNA-TF co-regulatory analysis, especially with a focus on cancers, are lacking. In light of this, we developed a web tool, namely CMTCN (freely available at http://www.cbportal.org/CMTCN), which constructs miRNA-TF co-regulatory networks and conducts comprehensive analyses within the context of particular cancer types. With its user-friendly provision of topological and functional analyses, CMTCN promises to be a reliable and indispensable web tool for biomedical studies.

【 授权许可】

CC BY