Translating the hemodynamic response: why focused interdisciplinary integration should matter for the future of functional neuroimaging

PeerJ

article

Sigita Cinciute¹ 

[1] Institute of Biosciences, Life Sciences Center, Vilnius University

关键词: Cerebrovascular regulation;    Healthcare;    Hemodynamic response;    Neuroscience;    Brain;    Computational modelling;    Functional near-infrared spectroscopy;    Neurovascular coupling;    Functional magnetic resonance imaging;   

DOI  :  10.7717/peerj.6621

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

The amount of information acquired with functional neuroimaging techniques, particularly fNIRS and fMRI, is rapidly growing and has enormous potential for studying human brain functioning. Therefore, many scientists focus on solving computational neuroimaging and Big Data issues to advance the discipline. However, the main obstacle—the accurate translation of the hemodynamic response (HR) by the investigation of a physiological phenomenon called neurovascular coupling—is still not fully overcome and, more importantly, often overlooked in this context. This article provides a brief and critical overview of significant findings from cellular biology and in vivo brain physiology with a focus on advancing existing HR modelling paradigms. A brief historical timeline of these disciplines of neuroscience is presented for readers to grasp the concept better, and some possible solutions for further scientific discussion are provided.

【 授权许可】

CC BY