The prognostic impact of age in different molecular subtypes of breast cancer: a population-based study

PeerJ

article

Dongjun Dai¹  Yiming Zhong¹  Zhuo Wang¹  Neelum Aziz Yousafzai¹  Hongchuan Jin²  Xian Wang¹ 

[1] Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University;Laboratory of Cancer Biology, Key Lab of Biotherapy, Sir Run Run Shaw Hospital, Medical School, Zhejiang University

关键词: Age;    Triple negative breast cancer;    Prognosis;    Competing risk model;    Breast cancer specific survival;    Molecular subtype;   

DOI  :  10.7717/peerj.7252

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundThe aim of current study was to use competing risk model to calculate the potential differences that age played in the prognosis of different breast cancer subtypes.MethodsThe cohort was selected from Surveillance, Epidemiology, and End Results (SEER) program. The cumulative incidences of death (CID) was assessed for breast cancer caused deaths and other causes of mortality. The multivariate Cox proportional hazards regression model and the multivariate subdistribution hazard (SH) model were used to evaluate the prognostic value of age in different breast cancer subtypes.ResultsWe involved 33,968 breast cancer patients into our cohort. We found older patients had worse overall survival (OS) than young patients in hormone receptor positive and human epidermal growth factor receptor 2 positive breast cancer (HR+/HER2+) (≥40 vs. <40, HR = 2.07, 95% CI [1.28–3.35], p < 0.05). However, when we used competing risk model, we found young age was an independent risk factor only for triple negative breast cancer (TNBC) (≥40 vs. <40, HR = 0.71, 95% CI [0.56–0.89], p < 0.05). No association was found in other groups.ConclusionOur research was currently the largest sample size study and the first competing risk model-based study on the prognostic association between age and different breast cancer subtypes. We found <40 years patients had worse breast cancer specific survival (BCSS) than older patients in the TNBC subtype.

【 授权许可】

CC BY