Comparison of olive leaf, olive oil, palm oil, and omega-3 oil in acute kidney injury induced by sepsis in rats

PeerJ

article

Rinaldo Florêncio da Silva¹  Ana Maria Soares Pereira²  Marcia Bastos Convento³  Fernanda Teixeira Borges³  Nestor Schor³  Maria Fátima de Paula Ramos³  Olvania Basso Oliveira³  Alceni do Carmo Morais Monteiro de Barros³  Clara Versolato Razvickas³  Edson de Andrade Pessoa³ 

[1] Morphology and Genetics Division, Universidade Federal de São Paulo;Biotechnology, Universidade de Ribeirão Preto;Nephrology Division, Department of Medicine, Universidade Federal de São Paulo;Interdisciplinary Postgraduate Program in Health Sciences, Universidade Cruzeiro do Sul

关键词: Lipopolysaccharide;    Olive oil;    Omega-3 oil;    Palm oil;    Kidney function;    Inflammation;   

DOI  :  10.7717/peerj.7219

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background Hypotension, increased production of reactive oxygen species, and inflammation are all observed in experimental models of sepsis induced by lipopolysaccharide (LPS). Purpose The aim of this study was to evaluate the effects of an ethanolic extract of Brazilian olive leaf (Ex), Brazilian olive oil (Olv), Ex + Olv (ExOlv), and palm oil (Pal) in comparison to the effects of omega-3 fish oil (Omg) in a rat model of sepsis-induced acute kidney injury. Materials Wistar rats were divided into seven groups (seven per group), which were either untreated (control) or treated with LPS, LPS + Ex, LPS + ExOlv, LPS + Olv, LPS + Omg, or LPS + Pal. Results Lower values of creatinine clearance and blood pressure were observed in the LPS-treated group, and these values were not affected by Ex, Olv, ExOlv, Pal, or Omg treatment. Mortality rates were significantly lower in rats exposed to LPS when they were also treated with Ex, ExOlv, Olv, Pal, or Omg. These treatments also decreased oxidative stress and inflammation (Tumor necrosis factor alpha, interleukin-1 beta) and increased interleukin-10 levels and cell proliferation, which were associated with decreased apoptosis in kidney tissue. Conclusion Ex and Pal treatments were beneficial in septic rats, since they increased survival rate and did not aggravate inflammation. However, the most effective treatments for septic rats were Olv in comparison to Omg. These natural food substances could enable the development of effective therapeutic interventions to sepsis.

【 授权许可】

CC BY